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    Scientists discover the secret to wrinkle-free skin

    19 Dec 2014 1:18 AM | Posted by
    Beth E's picture
    Beth E
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    Do you dream of getting smooth, wrinkle-free skin?

    Well, now you may be able to achieve just that, with Canadian scientists discovering what they believe is the key to erasing those pesky fine line and crows feet – for good.

    Interestingly, it all happened totally by accident. The researchers from the University of British Columbia set out to analyse the role of the enzyme Granzyme-B in heart attacks, and instead stumbled upon the wrinkle-fighting discovery

    As part of the experiment they created a miniature tanning salon for mice, exposing them to UV lamps.

    By week 20 of the study, it became clear that the mice that’d been engineered to lack the enzyme had noticeably smooth skin, while the control group had gotten wrinkles.

    According to the researchers, Granzyme-B causes wrinkles by affecting the integrity of collagen and dismantling the ‘cellular scaffolding’ that binds its cells together. This results in the structural weakness we identify as wrinkles. It all sounds a bit sciency, but basically the enzyme breaks down what holds collagen cells together, and ‘broken’ collagen means lines, wrinkles, crows feet, and laugh lines.

    Unfortunately, there’s still a way to go as far as banishing wrinkles in humans is concerned. While the mice were easily bred to have no Granzyme-B at all, the enzyme is actually part of our immune system and removing it could have unintended consequences.

    Still, the discovery is expected to lead to creams and treatments that could truly defy ageing, with the team busy developing drugs that can block the skin-ageing protein.  

    But until they’re commercially available, we recommend using a preventative high SPF sunscreen with moisturising properties, such as Invisible Zinc Tinted Daywear Anti-Ageing Facial Moisturising Sunscreen SPF 30+ or NIVEA Q10 plus Anti-Wrinkle Day Cream SPF 30+.

    For already existing wrinkles, a targeted serum is also a great idea. We love the powerful Mirenesse Power Lift Wrinkle Zero Night Renewal Serum as well as Balance Active Formula Wrinkle Free Serum (which contains snake venom for an added collagen boost).

    Are you concerned about fine lines and wrinkles? What other beauty-related discoveries would like you like to see made?

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    75 Member Comments

    Hayley644 3 Oct 2016 9:30 AM

    Gorgeous dog. Look at all those wrinkles.

    talk-a-lot 8 Apr 2016 2:12 PM

    Yes I often dream of having smooth wrinkle free skin. Ageing and damaged skin is what I want to combat.

    itslinda 6 Apr 2016 9:39 AM

    Great article

    Yohanna 24 Nov 2015 6:51 PM

    I clicked just to see the puppy! So cute :D hope these products are not tested on them :( or any other poor animals

    TheUglyDuckling 4 Sep 2015 7:01 PM

    I don't liken myself to that adorable Shar-Pei, but I would also like to prevent myself from looking like him (as adorable as he is).

    Beauty Hungry 14 May 2015 6:34 AM

    Yay,yikes- yes I want that gene to stop wrinkles forming. That mirenesse product is good for now!

    amikah100 10 Jan 2015 5:58 AM

    thats one cute dog!!

    Dianne542 7 Jan 2015 7:04 PM

    I think I will stay with what I use they help a bit. I don't like the testing on animals for a few less wrinkles

    Simone 5 Jan 2015 8:21 AM

    puppy is just too cute

    Miss_Lee 4 Jan 2015 9:37 AM

    I would be okay with wrinkles if I could look as cute as that pup!

    Goddess..... 2 Jan 2015 3:24 AM

    I dont want wrinkles yet.

    moonbaby54 31 Dec 2014 12:39 AM

    I don't have too many wrinkles for my age, and I don't have crows feet, but I still look my age,62, because I have other age related skin issues such as pigmentation etc. and my skin isn't as firm as it used to be :(

    Growing old 30 Dec 2014 4:35 AM

    IF only it was that easy lol! Tho no doubt in time ageing gracefully will be old fashion and they will look back at people with wrinkles and lines and be saying 'imagine having to look like that!' Lol! Not in my lifetime lol

    Shop A Everyday 30 Dec 2014 2:49 AM

    I aim to age gracefully

    Petal 30 Dec 2014 2:44 AM

    As much as I am not embracing the increase of wrinkles on my face, I will not be taking medication to stop them. Who knows what kind of side effects may result from them. I have a hard enough time taking Panadol if I have a headache!

    Jodie730 29 Dec 2014 3:07 AM

    Sounds great, though I don't like the idea of testing on animals

    Seezora 28 Dec 2014 1:00 PM

    I have laugh lines, and I'm not sure they'll ever go away no matter what I do, because I love to laugh ;D

    jatz 28 Dec 2014 11:52 AM

    awww that dog is so cute, even with the wrinkles. We all get them.

    rochelle1991 27 Dec 2014 12:37 AM

    Wow! amazing stuff!

    Linda_Vesinger 24 Dec 2014 2:12 PM

    I think the sun protection is a big key to wrinkle prevention

    bmill229 23 Dec 2014 11:23 AM

    Great article, different.

    emzaau 23 Dec 2014 10:32 AM

    Sun protection is my number one anti-aging weapon.

    Oonga 23 Dec 2014 7:49 AM

    I am kind of missing understanding how if you don't have the gene its going to help?

    OnFire 23 Dec 2014 6:42 AM

    I noticed my first fine line at 25yo.. I am now 27yo and do worry a little about getting more wrinkles so try and protect myself the best I can. I ALWAYS use SPF on my skin (it's in my BB cream which is in my basic routine) and always ensure my face and décolletage is in the shade/covered if in the sun or at the beach.

    robyn smithwick 23 Dec 2014 6:01 AM

    What a very interesting, informative article. I wonder how long it will be before they start testing it on humans?

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